Over 6 million people in the US are living with Alzheimer disease (AD)1, and over 80 million adults between 50-70 years whose biggest health fear, other than cancer, is AD2.
We want to help them all.
Labcorp is proud to offer the broadest blood-based biomarker portfolio for Alzheimer’s disease and dementia
Each of the Alzheimer’s biomarker tests are orderable individually
484390
Phosphorylated Tau 217 (pTau-217), Plasma
An aid in the identification of Alzheimer's disease pathology by detecting the presence or absence of pTau-217, which has been shown in the literature to be a surrogate of amyloid pathology. Additionally, pTau-217 can be used for monitoring patients on newly approved anti-amyloid therapies
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505725
Beta Amyloid 42/40 Ratio, Plasma
Labcorp’s Beta-Amyloid 42/40 Ratio test quantifies the amount of beta-amyloid 42 and 40 proteins in a plasma patient sample and computes the ratio of those proteins, providing an indication of amyloid pathology for Alzheimer’s disease
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484440
Glial Fibrillary Acidic Protein (GFAP)
GFAP is a protein expressed mostly in astrocytes in the brain. In conjunction with markers of amyloid pathology, GFAP has been shown to be a predictor of Alzheimer's disease
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140555
Neurofilament Light Chain, Plasma
NfL, in the context of Alzheimer’s disease, provides an indication of disease severity by measuring the current level of neurodegeneration
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483745
Phosphorylated Tau 181 (pTau-181), Plasma
This test detects and quantifies pTau-181 proteins in plasma, which has been demonstrated to be predictive in differentiating Alzheimer’s from other dementias
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484400
ATN Profile
This profile is used to assist in determining the presence or absence of key biological changes that are consistent with Alzheimer's disease pathology
Alzheimer Disease Evaluation Profile, CSF (484415)
Labcorp’s Alzheimer’s Disease Evaluation Profile measures β‑Amyloid (1‑42) (Abeta42), total Tau (tTau) and Phospho‑Tau (181P) (pTau181) protein concentrations in cerebrospinal fluid (CSF) from adult patients aged 55 years and older being evaluated for Alzheimer's disease (AD) and other causes of cognitive impairment to generate a to generate a tTau/Abeta42 ratio value and a pTau181/Abeta42 ratio value.
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Beta Amyloid 42/40 Ratio, CSF (505560)
Labcorp's Beta-Amyloid 42/40 Ratio test quantifies the amount of beta-amyloid 42 and 40 proteins in a CSF patient sample and computes the ratio of those proteins, providing an indication of disease progression. Studies have shown strong correlation of CSF beta-amyloid levels to PET scan results. This test can be a surrogate to more costly PET scan imaging.
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APOE Alzheimer’s Risk (125536)
This test detects the presence of the Apolipoprotein E (APOE)-4 variant, which is associated with increased risk of late-onset (age >60-65) Alzheimer's disease (AD). Testing may be considered for patients with dementia to supplement information from clinical and other evaluations. APOE has multiple roles, including lipid transport in the blood and the brain. The APOE4 variant increases the risk for late-onset Alzheimer's disease and may contribute to the pathology of the disease through influence on β-amyloid, inflammation, or other processes.
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Early Onset Alzheimer's NGS Diagnostic Test (630557)
AD is a complex and heterogeneous disease, influenced by many genetic and environmental factors. Early onset familial AD (presenting between 25-60) occurs in less than 2% of AD cases. This test analyzes three genes (amyloid protein precursor (APP), presenilin 1 (PSEN1) and presenilin 2 (PSEN2)) to detect pathogenic variants that cause autosomal dominant early onset Alzheimer's disease. Testing may be considered to confirm a diagnosis of early onset Alzheimer's disease in symptomatic individuals.
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Labcorp offers neurological biomarkers for Biopharma
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References
- Alzheimer’s Association. https://www.alz.org/alzheimers-dementia/facts-figures
- Anderson LA, Day KL, Beard RL, et.al. "The Public's Perceptions About Cognitive Health and Alzheimer's Disease Among the U.S. Population: A National Review". The Gerontologist. 2009; 49(S1): S3-S11.
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